High-resolution spatial analysis reveals pregnenolone metabolism as a potential target for immuno-suppressive microenvironment of BRAF mutant colorectal cancer
Xicheng Wang, Zihao Zhao, Lian Liu, Jie Cheng, Yi Ba
This study identifies pregnenolone metabolism as an immunosuppressive pathway in BRAF mutant colorectal cancer using spatial analysis and single-cell RNA sequencing.
bioRxiv · Sep 1, 2025 · PreprintCancer Biology