Author

Lian M.C. Jacobs

University of South Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Aiden C Jaskolka-BrowniD· 1 shared Aliaksandra Frazier· 1 shared Eric M. LewandowskiiD· 1 shared Haozhou TaniD· 1 shared Jesper J. MadseniD· 1 shared Jun WangiD· 1 shared Navita Kohaal· 1 shared Xiujun ZhangiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperMolecular Biology

Aiden C Jaskolka-BrownORCID

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1 paper

Recent·Most cited

Distal Protein-Protein Interactions Contribute to SARS-CoV-2 Main Protease Substrate Binding and Nirmatrelvir Resistance

Eric M. Lewandowski, Xiujun Zhang, Haozhou Tan, Aiden C Jaskolka-Brown, Navita Kohaal, Aliaksandra Frazier, Jesper J. Madsen, Lian M.C. Jacobs, Jun Wang, Yu Chen

This study shows that non-active site mutations in SARS-CoV-2 Mpro enhance dimer-dimer interactions, aiding substrate binding and resistance to nirmatrelvir.

bioRxiv · Apr 1, 2024 · PreprintMolecular Biology