Molecular BiologybioRxivPreprint
Distal Protein-Protein Interactions Contribute to SARS-CoV-2 Main Protease Substrate Binding and Nirmatrelvir Resistance
Eric M. Lewandowski, Xiujun Zhang, Haozhou Tan…·Yu Chen
This study shows that non-active site mutations in SARS-CoV-2 Mpro enhance dimer-dimer interactions, aiding substrate binding and resistance to nirmatrelvir.