Restoration of Susceptibility of blaNDM-bearing Escherichia. coli to Carbapenem Antibiotics by Exogenous N-acetylcysteine
Dexi Li, Yuzhe Zhao, Xinyu Guo, Chenglong Li, Yage Sun, Yixin Wang, Lijuan Chang, Xiaoming Wang, Yanling Wang, Štefan Schwarz, Xiang‐Dang Du
This study shows that N-acetylcysteine restores carbapenem susceptibility in NDM-producing E. coli through three mechanisms: inhibiting biofilm formation, downregulating blaNDM-5, and enhancing meropenem intracellular accumulation.
bioRxiv · Mar 31, 2025 · PreprintPharmacology & Toxicology