Yanling Wang

Multimodal Analysis of Transcriptional Regulation in the Dorsolateral Prefrontal Cortex Enhances Alzheimer's Disease Risk Gene Discovery

This study uses multimodal transcriptomic data to enhance Alzheimer's disease risk gene discovery, identifying 161 risk genes with proteomic support and an interconnected network of hub genes.

Altered microglial communication in brains with Alzheimers Disease pathology

The paper analyzes microglial communication in Alzheimer's disease using single-nucleus RNA sequencing to identify altered signaling pathways and cell interactions associated with disease pathology.

Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer's disease heterogeneity

This study integrates multi-omics data from aged human brains to identify cross-system biological factors and molecular subtypes associated with Alzheimer's disease heterogeneity.

The Bacteriocin Sublancin Restores Vancomycin efficacy against vancomycin-resistant enterococci in vitro and in vivo

This study shows that sublancin, a bacteriocin, enhances vancomycin's effectiveness against vancomycin-resistant enterococci in vitro and in vivo by down-regulating resistance genes.

A Multi-omic Atlas of Human Choroid Plexus in Alzheimer's Disease

This study creates a multi-omic atlas of the choroid plexus in Alzheimer's disease, identifying disease-associated cell state transitions and functional impairments.

Blood-based Transcriptomics Reveal Sex- and Amyloid-Modulated Biology of Plasma pTau217 in Preclinical Alzheimer's Disease

The paper identifies gene associations with plasma pTau217 in preclinical Alzheimer's disease, showing modulation by APOEε4, Aβ-PET, and sex, with X-linked genes playing a role.

Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimers Disease

The paper identifies cell type-specific gene modules associated with Alzheimer's Disease traits using snRNASeq data from human brain tissues.

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance

The paper examines sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive performance using bulk transcriptomic data from 767 individuals.

Cytokine expression profile in the human brain of older adults

This study examines cytokine gene expression in human brain tissue from elderly individuals with and without Alzheimer's disease to identify biomarkers and understand disease mechanisms.

Modeling Stimulus-Induced Stress Responses in Microglia-like Cells Using a Commercial iPSC-dCas9-KRAB Line

The paper evaluates the AICS-0090 dCas9-KRAB iPSC line for modeling microglia-like cells and their responses to disease-relevant stimuli, finding stimulus-specific transcriptomic and functional responses.

Establishment of a Systemic Lupus Erythematosus Mouse Model in Humanized CD3/CD19 Mice and Evaluation of the Efficacy of a Human Bispecific Antibody

This paper establishes a humanized CD3/CD19 mouse model of SLE and evaluates the efficacy of a human bispecific antibody in treating the disease.

Characterizing Post-Mortem Brain Molecular Taxonomy of Cognitive Resilience and Translating it to Living Humans

The paper defines cognitive resilience as differential cognitive decline rates after adjusting for neuropathologies, develops a framework to quantify it using molecular signatures from post-mortem brain data, and translates these findings to living individuals.

Brain Multi-Omic Subtypes of Neuroticism Reveal Molecular Signatures linked to Alzheimer's Disease

The paper identifies three brain multi-omic molecular subtypes of neuroticism linked to Alzheimer's disease traits, with subtype N1 showing the strongest associations.

TDP-43 toxic gain of function links ALS, FTD and Alzheimers Disease through splicing dysregulation

This study identifies TDP-43-driven splicing dysregulation as a common mechanism in ALS, FTD, and Alzheimer's disease, linking them through mis-spliced mRNAs like APP.

Restoration of Susceptibility of blaNDM-bearing Escherichia. coli to Carbapenem Antibiotics by Exogenous N-acetylcysteine

This study shows that N-acetylcysteine restores carbapenem susceptibility in NDM-producing E. coli through three mechanisms: inhibiting biofilm formation, downregulating blaNDM-5, and enhancing meropenem intracellular accumulation.

Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans

This study translates post-mortem brain multi-omics AD dementia subtypes into blood, MRI, and psychological markers in living individuals.

Integrated Spatial and Single-Nuclei Transcriptomic Analysis of Long Non-Coding RNAs in Alzheimer's Disease

The paper identifies AD-associated lncRNAs with spatial and cell-type-specific expression patterns and shows OIP5-AS1 contributes to microglial activation in AD.

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations

This paper presents a multi-omics dataset from multi-ethnic Alzheimer's disease brain donors, including transcriptome, genome, and proteome data, to improve precision medicine for underrepresented populations.

CHRNA5 links chandelier cells to severity of amyloid pathology in human aging and Alzheimer's Disease

The paper investigates CHRNA5's role in amyloid pathology in aging and Alzheimer's by analyzing genetic variants and cell-type expression in human brain tissue.

Dissecting the Human Leptomeninges at single-cell resolution

This study provides the first single-nuclei profiling of human leptomeninges, identifying cell types and gene expression patterns linked to Alzheimer's disease.

SR-TWAS: Leveraging Multiple Reference Panels to Improve TWAS Power by Ensemble Machine Learning

SR-TWAS improves TWAS power by combining multiple reference panels and regression methods through ensemble learning, identifying risk genes for Alzheimer's and Parkinson's diseases.

Multi-'Omic Integration via Similarity Network Fusion to Detect Molecular Subtypes of Aging

This paper uses multi-omic integration to identify molecular subtypes of aging in brain tissue, finding subtypes associated with cognitive decline.

Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

Decoding differential gene expression

This paper introduces DEcode, a deep learning model that improves differential gene expression prediction by integrating systems biology data, showing post-translational RNA-binding factors are key regulators.