A multistage, dual voxel study of glutamate in the anterior cingulate cortex in schizophrenia supports a primary pyramidal dysfunction model of disorganization
Lejia Fan, Zhenmei Zhang, Xiaoqian Ma, Liangbing Liang, Yujue Wang, Yuan Liu, Lijun Ouyang, Zongchang Li, Xiaogang Chen, Ying Hé, Lena K. Palaniyappan
The paper investigates glutamate levels in the anterior cingulate cortex across different schizophrenia risk stages, finding reduced glutamate in genetic high risk and higher glutamate in clinical high risk, linking glutamate changes to disorganization symptoms.
bioRxiv · Nov 27, 2023 · PreprintNeuroscience