Lena K. Palaniyappan

This study investigates how leader and follower roles shape brain mechanisms in dyadic sensorimotor coordination using EEG hyperscanning, finding role-specific neural patterns and dissociating automatic from controlled coordination.

The paper identifies three depression subtypes using plasma proteomics, linked to inflammation, aging, and metabolic factors, with distinct clinical and neurobiological features.

This study identifies reduced beta-band neural modulation as a shared mechanism linking perceptual, motor, and language impairments in schizophrenia.

This study examines beta-burst dynamics in schizophrenia patients and controls, finding dissociable anterior and posterior abnormalities linked to speech markers of thought disorder.

This study shows that subanesthetic ketamine disrupts corollary discharge signaling in the prefrontal cortex of macaques, impairing predictive mechanisms linked to schizophrenia.

This study examines white matter changes in schizophrenia patients over two to three years post-onset and finds no longitudinal differences but links white matter alterations to negative symptoms.

The paper shows that changes in spontaneous speech structure reflect disrupted cortical hierarchy in first-episode psychosis, linking language and brain organization.

This study uses neuromelanin-MRI to show that cannabis use disorder is associated with elevated dopamine signaling in specific midbrain regions, suggesting shared mechanisms with psychosis.

The paper applies the NODDI model to early psychosis patients and healthy controls to assess microstructural changes in grey and white matter, finding increased free water in grey matter not fully explained by partial volume effects.

This paper uses GPT-3 to quantify global vs. local context sensitivity in speech from schizophrenia patients and finds disorganized speech shows insensitivity to global context, predicting positive thought disorder.

The paper investigates white matter and cortical network changes in early psychosis and finds minimal disruption in first-episode psychosis compared to chronic patients and controls.

The paper investigates glutamate levels in the anterior cingulate cortex across different schizophrenia risk stages, finding reduced glutamate in genetic high risk and higher glutamate in clinical high risk, linking glutamate changes to disorganization symptoms.

This study uses 7-Tesla MRS to track longitudinal changes in brain metabolites in FEP patients and healthy controls, identifying potential trait and state markers for psychosis.

This study evaluates the test-retest reliability and sex/age-related effects on the temporal clustering coefficient of dynamic brain networks using resting-state fMRI data from the Human Connectome Project.

The paper investigates how macaque lateral prefrontal cortex neurons encode working memory and perceptual representations during naturalistic vision in a virtual environment.

This study shows that neural sequences in primate prefrontal cortex encode working memory in naturalistic environments through sequential neuron activation.

The paper examines myelin and microstructural changes in basal forebrain cholinergic nuclei in first-episode psychosis using neuroimaging and transcriptomic data, finding disrupted correlations and clinical correlates.

This study shows that primate lateral prefrontal cortex encodes working memory representations during naturalistic behavior and that ketamine disrupts this encoding by altering neuronal firing patterns.

This study links higher brain glutathione levels to faster treatment response in first episode psychosis patients using 7-Tesla MRS.

The paper uses dynamic causal modeling on resting-state fMRI to examine how left prefrontal stimulation affects positive symptoms of schizophrenia, finding delusions are linked to fronto-striatal circuitry.

This study examines altered cortical gyrification in very preterm adults and its links to cognitive and mental health outcomes.

The paper investigates glutamate levels and effective connectivity in the salience network of schizophrenia patients using multimodal imaging and cognitive tasks, finding links between glutamate and connectivity deficits.

The paper examines cortical sulcation differences between schizophrenia patients and controls to determine the timing of prenatal insults, finding that schizophrenia-related disruptions predate cognitive deficits.

This study examines structural connectivity diversity in schizophrenia using DTI, finding reduced topographic diversity in patients compared to controls, suggesting a common pathway underlying the disease's heterogeneity.

The paper uses neuroimaging and gene expression data to show that hippocampal volume reductions in first-episode psychosis correlate with serotonin receptor densities and glutamate receptor gene expression.

This study investigates neurovascular uncoupling in schizophrenia using a bimodal meta-analysis of brain perfusion and glucose metabolism, finding region-specific abnormalities and discordance.

This paper models theta-band connectivity between occipital and frontal lobes using MEG data from schizophrenia patients and healthy controls, finding differences in wave speed modulation by task condition.