The AP-1 complex regulates AXL expression and determines sensitivity to PI3Kα inhibition in esophagus and head and neck squamous cell carcinoma
Mai Bdarny, Manu Prasad, Noa Balaban, Joshua Ben-Zion, Anat Bahat Dinur, Reidar Grénman, Limor Cohen, Moshe Elkabets
This study shows that AP-1 factors regulate AXL expression, which contributes to resistance to PI3Kα inhibition in ESCC and HNSCC, and that JNK inhibition combined with PI3Kα inhibition enhances anti-tumor effects.
bioRxiv · Oct 8, 2018 · PreprintCancer Biology