Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression and fibrosis through PI3K/AKT/PDGF axis activation
Qian Ye, Yi Liu, Guiji Zhang, Haijun Deng, Qiang Wang, Lin Tuo, Chang Chen, Xuanming Pan, Kang Wu, Jian‐Gao Fan, Qin Pan, Kai Wang, Ailong Huang, Ni Tang
This study shows that PCK1 deficiency worsens NASH by activating the PI3K/AKT/PDGF axis, leading to fibrosis and inflammation.
bioRxiv · Jan 12, 2021 · PreprintMolecular Biology