Molecular BiologybioRxivPreprint
Deficiency of gluconeogenic enzyme PCK1 promotes non-alcoholic steatohepatitis progression and fibrosis through PI3K/AKT/PDGF axis activation
Qian Ye, Yi Liu, Guiji Zhang…·Ni Tang
This study shows that PCK1 deficiency worsens NASH by activating the PI3K/AKT/PDGF axis, leading to fibrosis and inflammation.
4 citations