Hypoxia-induced ALDH7A1 expression protects colorectal cancer cells from oxidative stress and DNA damage via a HIF-1-independent mechanism
Lina Elsalem, Simon J. Allison, Maria Sadiq, Abdullahi Magaji Dauda, Krishna Khullar, Mark Sutherland, Steven D. Shnyder, Syed Ali Khurram, Roger M. Phillips, Jan S. Moreb, Sneha Smarakan, Klaus Pors
This study shows hypoxia increases ALDH7A1 in colorectal cancer cells, which reduces oxidative stress and DNA damage without needing HIF-1.
bioRxiv · Aug 19, 2026 · PreprintCancer Biology