Physiological bias governs neutrophil inflammatory threat perception
Denise Pajonczyk, Lina Pauli, Charlotte Pünt, Merle F. Sternschulte, Olesja Fehler, Thomas Vogl, Oliver Soehnlein, Marcel Bermúdez, Carsten Alexander Raabe, Ursula Rescher
The paper shows that the cellular environment significantly affects GPCR signaling, leading to physiological bias in neutrophils that impacts drug efficacy.
bioRxiv · Apr 5, 2024 · PreprintSystems Biology