Carsten Alexander Raabe

The paper compares FPR1 and FPR2 signaling profiles using agonists, finding shared core signatures and low activity ratios for FPR2 agonists, challenging assumptions about receptor-specific inflammatory profiles.

The paper shows that the cellular environment significantly affects GPCR signaling, leading to physiological bias in neutrophils that impacts drug efficacy.

This study identifies a circular RNA, circAβ-a, that translates into Aβ175, which is processed into Aβ peptides, revealing an alternative pathway for Aβ biogenesis in Alzheimer's disease.