Conformational dynamics in the membrane interactions of bispecific targeted degrader therapeutics
Emma Inganäs, Hanna Lavén, Rémi Caraballo, Fredrik Klingegård, MyLan Eklund, Linda Andersson, Constanze Hilgendorf, Pär Matsson
This study analyzes over 3500 PROTACs to determine how linker design and molecular properties affect cell permeability and intracellular exposure.
Journal of Medicinal Chemistry · Dec 10, 2025Peer-reviewedPharmacology & Toxicology