Author

Fredrik Klingegård

Science for Life LaboratoryORCID 0000-0001-6280-3894Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Rémi CaraballoiD· 2 shared Ann‐Sofie JemthiD· 1 shared Constanze HilgendorfiD· 1 shared Dante RotiliiD· 1 shared Emma InganäsiD· 1 shared Eri van Berkum· 1 shared Gabriel Tidestav· 1 shared Hanna LavéniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Rémi CaraballoORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewedDec 10, 2025

Conformational dynamics in the membrane interactions of bispecific targeted degrader therapeutics

Emma Inganäs, Hanna Lavén, Rémi Caraballo…·Pär Matsson

This study analyzes over 3500 PROTACs to determine how linker design and molecular properties affect cell permeability and intracellular exposure.

9 citations

statistical modeldrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivPreprintJun 13, 2025

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs

Seher Alam, Maria Joao Almeida A Silva Pires, Gabriel Tidestav…·Mikael Altun

This paper introduces a cell-based platform to assess PROTACs targeting NUDT5, identifying a VHL-dependent degrader despite poor in vitro binding and showing CRBN-dependent degraders are ineffective.

1 citation

humanproteomics

𝕏 PostBluesky