Role of transmembrane spanning domain 1 in cystic fibrosis transmembrane conductance regulator folding
Anna E. Patrick, Linda Millen, Philip Thomas
This study examines how mutations in the transmembrane spanning domain 1 (TMD1) of CFTR affect its folding and trafficking, showing that some effects are apparent only after TMD2 production.
bioRxiv · Feb 2, 2021 · PreprintMolecular Biology