Philip Thomas

A physiological role for GABAA receptor desensitization - induction of long-term potentiation at inhibitory synapses

This study identifies a new form of long-term potentiation at inhibitory synapses induced by GABAA receptor desensitization, showing it enhances synaptic current amplitude through PKC-mediated receptor phosphorylation.

Role of transmembrane spanning domain 1 in cystic fibrosis transmembrane conductance regulator folding

This study examines how mutations in the transmembrane spanning domain 1 (TMD1) of CFTR affect its folding and trafficking, showing that some effects are apparent only after TMD2 production.

Brain neurosteroids are natural anxiolytics targeting α2 subunit γ-aminobutyric acid type-A receptors

This study identifies 2-GABAAR as a key target for neurosteroid anxiolytic effects, showing its importance for anxiety but not depression or analgesia.