PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activation
Jacob Deyell, Jonathan Hasselmann, Linda Stroud, Urmimala Raychaudhuri, Yunzi Guo, Byeonggu Cha, Christopher Karma, Deavin Tendean, Minh-Huy Vu Tran, Anastasia Gromova, Audrey S. Dickey, Mathew M. Blurton-Jones, Albert R. La Spada
This study shows PPARδ activation in microglia reduces inflammation and enhances phagocytic function, shifting microglia toward a disease-associated state in neurodegenerative models.
bioRxiv · Dec 19, 2025 · PreprintNeuroscience