Mathew M. Blurton-Jones

Upregulation of Calbindin in Adult Inhibitory Neurons Reactivates Critical Period Plasticity in Mouse Visual Cortex

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.

Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotection

The paper develops a humanized neuroimmune model to study tauopathy and identifies microglial and lncRNA mechanisms that protect neurons.

Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer's disease

The paper examines proteasome composition and activity in human iPSC-derived cortical neurons from early-stage sporadic Alzheimer's disease patients, finding increased 20S proteasome assemblies and proteolytic activity.

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons

This study shows DNA damage in neurons leads to a senescent-like state similar to Alzheimer's disease, with distinct features from fibroblasts.

Reduced LACTB expression in myeloid cells is associated with elevated succinylcarnitine levels and reduced Alzheimers disease risk.

The paper investigates the role of LACTB in Alzheimer's disease risk through Mendelian Randomization and experimental models, finding reduced LACTB expression lowers AD risk and increases succinylcarnitine levels.

PPARδ activation in microglia drives a transcriptional response that primes phagocytic function while countering inflammatory activation

This study shows PPARδ activation in microglia reduces inflammation and enhances phagocytic function, shifting microglia toward a disease-associated state in neurodegenerative models.

INPP5D/SHIP1 regulates endo-lysosome function and cargo-selective phagocytosis in human microglia

This study shows that INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia, linking its dysfunction to Alzheimer's disease pathology.

Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion

This study identifies microglia-dependent and independent mechanisms of lipid dysregulation in Alzheimer's disease using mouse models and lipidomics.

Circulatory proteins shape microglia state and boost phagocytosis

The paper identifies a microglia population that takes up circulatory proteins, enhancing phagocytosis and innate immunity through ApoA-I uptake.

Microglia are not required for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism

The paper investigates the role of microglia in maintaining blood-brain barrier properties in health and finds that microglia are not required, but PLX5622 treatment affects endothelial cholesterol metabolism.

Organelle phenotyping and multi-dimensional microscopy identify C1q as a novel regulator of microglial function.

The paper introduces an organelle phenotyping approach using live-cell microscopy to identify C1q as a regulator of microglial function, showing its role in fatty acid storage and mitochondrial membrane potential.

ER and SOCE Ca2+ signals are not required for directed cell migration in human microglia

This study shows that ER and SOCE Ca2+ signals are not required for directed migration of human microglia in response to purinergic stimuli, suggesting a Ca2+-independent mechanism involving cyclic AMP.

Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model.

This study investigates mitochondrial dysregulation's role in neurodegeneration after contusion injury using a 3D in vitro triculture model of human brain cells.

A resource for generating and manipulating human microglial states in vitro

This paper develops a platform to model and manipulate human microglial states in vitro using single-cell RNA sequencing and genetic tools, identifying disease-associated transcriptional signatures.

Integrated transcriptome analysis of Huntingtons disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturation

This study compares HD astrocytes from human iPSCs and mouse models, identifying dysregulated synaptogenesis, actin signaling, and maturation, with unique human findings and potential therapeutic targets.

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.

A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant-negative impact on CSF1R signaling.

This study investigates a kinase-dead Csf1r mutation in mice, showing it causes dominant-negative effects on CSF1R signaling and impacts macrophage development and brain microglia.

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

This study investigates the ability of the quorum sensing peptide PapRIV to activate BV-2 microglia and cross biological barriers, showing in vitro activation and in vivo presence.

Cellular and molecular phenotypes of C9orf72 ALS/FTD patient derived iPSC-microglia mono-cultures

This study examines C9orf72 ALS/FTD patient-derived iPSC-microglia mono-cultures, finding they form RNA foci, have reduced C9orf72 protein, and show endosomal-lysosomal dysfunction, but no significant microglial-enriched gene expression differences.