Myelinated mechano-nociceptors encode noxious cold and underlie hypersensitivity in pulpitis
Elizabeth A. Ronan, Shuhao Wan, Sienna K. Perry, Aditi Jha, Akash R. Gandhi, Jingchen Xu, Sabrina T. Wang, Lindsey L. Wu, Kevin Patrick Pipe, Joshua J. Emrick
This study identifies myelinated high threshold-mechanonociceptors as the neural basis for tooth cold sensitivity and shows their role in hypersensitivity during pulpitis.
bioRxiv · Oct 5, 2026 · PreprintNeuroscience