Clonal morphology-guided combination therapies overcome heterogeneity-driven drug tolerance
X W Li, Ling Liu, Yuanyuan Yan, Mengfang Yang, Lingli Luo, Yong Jiang, Weijun Ren
This study identifies clonal morphology as a marker of tumor heterogeneity and shows that clone-selective drug combinations can overcome resistance by targeting distinct clonal populations.
bioRxiv · Feb 3, 2026 · PreprintCancer Biology