Increased Infectivity of Human Cytomegalovirus Strain TB40/E Conferred by Variants of the Envelope Glycoprotein UL128 and the Regulatory Protein IE2
Xuan Zhou, Linjiang Yang, Giorgia Cimato, Giada Frascaroli, Ana Águeda-Pinto, Laura Hertel, Wolfram Brune
This study identifies two SNVs in HCMV strain TB40/E that enhance infectivity and syncytium formation in epithelial and macrophage cells by altering UL128 splicing and IE2 function.
Journal of Virology · Aug 11, 2025Peer-reviewedMicrobiology