Evolution and instability of human centromeres are accelerated by heterochromatin boundary loss and CENP-A overexpression
Megan A. Mahlke, Angela Enriquez, Lior Lumerman, Poulomi Nath, Cy Chittenden, Savannah J. Hoyt, Jonas Koeppel, Yuan Xu, Rebecca Raphael, Kylie Zaffina, Paul W. Hook, Winston Timp, Karen H. Miga, Peter J. Campbell, Rachel J. O’Neill, , Yael Nechemia‐Arbely
The paper shows that human centromeres and neocentromeres evolve epigenetically, with instability linked to loss of heterochromatin boundaries and CENP-A overexpression.
Cell Reports · Aug 1, 2026Peer-reviewedCell Biology