The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus
Lei Li, Guanghao Wu, Xiaolei Xu, Junling Yang, Lirong Yi, Ziqing Yang, Zheng Mo, Xing Li, Ying Shan, Zhuo Yu, Yinchuan Li
This study uses snRNA-seq to show that 17-estradiol treatment in aged rats reduces aging-related neuronal stress and alters HPG axis activity and energy metabolism.
eLife · Sep 25, 2025Peer-reviewedNeuroscience