Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea
Sandra de Haan, Agustín Andrés Corbat, Christopher Robin Cederroth, Lisa G. Autrum, Simona Hankeová, Elizabeth Carroll Driver, Barbara Canlon, Matthew W. Kelley, Emma Rachel Andersson
This study investigates the role of Jag1 in repressing Notch activation in lateral supporting cells and its impact on outer hair cell development in the cochlea using a mouse model of Alagille syndrome.
bioRxiv · Feb 2, 2024 · PreprintDevelopmental Biology