Author

Simona Hankeová

GenentechORCID 0000-0002-7797-3818Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Emma Rachel AnderssoniD· 3 shared Elisabeth VerboveniD· 2 shared Noémi Van HuliD· 2 shared Adel ElSohly· 1 shared Afshan IqbaliD· 1 shared Agustín Andrés CorbatiD· 1 shared Amy Shelton· 1 shared Andrew H. JheoniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersDevelopmental Biology

Emma Rachel AnderssonORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hypothalamic oligodendrocytes regulate systemic energy balance through Notch-dependent state transitions

Simona Hankeová, Margaret Hayne, Mathijs P. Verhagen, Greg Farber, Michelle Dourado, Dewakar Sangaraju, Kayla Lee, Praveen Krishnamoorthy, Ronal Peralta, Kerstin Seidel, Kai Barck, Amy Shelton, Manal Sadek, Pamela Chan, Adel ElSohly, , Lluc Mosteiro

This study identifies Notch signaling in hypothalamic oligodendrocytes as a regulator of systemic energy balance, showing that inhibiting Notch ligands leads to weight loss and metabolic changes.

bioRxiv · Jul 31, 2026 · PreprintPhysiology

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea

Sandra de Haan, Agustín Andrés Corbat, Christopher Robin Cederroth, Lisa G. Autrum, Simona Hankeová, Elizabeth Carroll Driver, Barbara Canlon, Matthew W. Kelley, Emma Rachel Andersson

This study investigates the role of Jag1 in repressing Notch activation in lateral supporting cells and its impact on outer hair cell development in the cochlea using a mouse model of Alagille syndrome.

bioRxiv · Feb 2, 2024 · PreprintDevelopmental Biology

Sex differences and risk factors for bleeding in Alagille syndrome

Simona Hankeová, Noémi Van Hul, Jakub Laznovsky, Elisabeth Verboven, Katrin Mangold, Naomi Hensens, Csaba Ádori, Elvira Verhoef, Tomáš Zikmund, Feven Dawit, Michaela Kavková, Jakub Šalplachta, Marika Sjöqvist, Bengt R. Johansson, Mohamed G. Hassan, , Emma Rachel Andersson

The paper identifies sex differences in bleeding risk and explores non-invasive vascular analysis in Alagille syndrome using mouse models and retinography.

EMBO Molecular Medicine · Nov 8, 2022Peer-reviewedDevelopmental Biology

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis

Jan Mašek, Iva Filipovic, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Daniel V. Oliveira, Anna Maria Frontino, Simona Hankeová, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, , Emma Rachel Andersson

This study shows that Jag1 deficiency in a mouse model of Alagille syndrome leads to impaired liver fibrosis due to defective T cell differentiation and hepatocyte maturation.

bioRxiv · Oct 24, 2022 · PreprintDevelopmental Biology