Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology
Sumit Mukherjee, Sumeet Patiyal, Lipika R. Pal, Keluo Yao, Tiangen Chang, Sumona Biswas, Saugato Rahman Dhruba, Amos Stemmer, Arashdeep Singh, Abbas Yousefi-Rad, Tien-Hua Chen, Binbin Wang, Denis Marino, Wonwoo Shon, Yuan Yuan, , Eytan Ruppin
This paper introduces TIME_ACT, a transcriptomic signature predicting immune checkpoint blockade response across cancers, validated using histopathology and multiple cohorts.
bioRxiv · Jun 27, 2025 · PreprintCancer Biology