Yuan Yuan

Path2Space predicts spatial gene expression and tumor microenvironment from histopathology slides, identifying new breast cancer subgroups and improving biomarker prediction.

This paper introduces TIME_ACT, a transcriptomic signature predicting immune checkpoint blockade response across cancers, validated using histopathology and multiple cohorts.

This study characterizes mitochondrial genomes in 2,700 cancer patients across 37 types using whole-genome sequencing and RNA-seq, revealing mutational patterns, truncating mutations, and nuclear transfer of mitochondrial DNA.