Haematopoietic loss of KDM6A impairs cardiac recovery in heartfailure via epigenetic reprogramming of myeloid cells
Emmanouil G Solomonidis, Dennis Hecker, Mariana Shumliakivska, Julian Leberzammer, Ariane Fischer, Minh-Thuy Katschke, Melanie Bendel, Lara Korth, Bianca Schuhmacher, Laura Rumpf, Simone-Franziska Glaser, Katja Schmitz, Guillermo Luxán, Silke Frenz, Penelope Pennoyer, , Sebastian Cremer
This study shows that loss of KDM6A in hematopoietic cells impairs cardiac recovery after heart failure by causing epigenetic changes in myeloid cells that increase inflammation and worsen cardiac outcomes.
bioRxiv · Dec 2, 2025 · PreprintCell Biology