Multiomic State-Transitions Reveal Post-Treatment Transcriptome Desynchronization in Acute Myeloid Leukemia
Jennifer Rangel Ambriz, Ziang Chen, Yu-Hsuan Fu, David Eugene Frankhouser, Denis O’Meally, Lisa Uechi, Lianjun Zhang, Ying‐Chieh Chen, Sergio Branciamore, Jihyun Irizarry, Bin Zhang, Guido Marcucci, Russell C. Rockne, Ya‐Huei Kuo
The paper uses a state-transition model to study transcriptome dynamics in AML, finding delayed miRNA responses and linking the Dlk1-Dio3 locus to treatment-induced desynchronization.
bioRxiv · Jul 7, 2026 · PreprintCancer Biology