Gene-gene and Gene-Environment Interactions Improve Genetic Risk Predictions for Complex Diseases
Keri Multerer, Paul Atkinson, Binh Phu Nguyen, Lisa Woods, Yosuke Tanigawa, M Kellis, Andrew B. Munkacsi
This paper develops an extended polygenic risk score (ePRS) framework for type 2 diabetes that incorporates gene-gene and gene-environment interactions, showing improved predictive power over traditional additive models.
medRxiv · Aug 17, 2026 · PreprintGenetic & Genomic Medicine