Genetic & Genomic MedicinemedRxivPreprint
Gene-gene and Gene-Environment Interactions Improve Genetic Risk Predictions for Complex Diseases
Keri Multerer, Paul Atkinson, Binh Phu Nguyen…·Andrew B. Munkacsi
This paper develops an extended polygenic risk score (ePRS) framework for type 2 diabetes that incorporates gene-gene and gene-environment interactions, showing improved predictive power over traditional additive models.
DOI 10.64898/2026.08.12.26360291