TLR7 Signaling Regulates Embryonic Hematopoietic Stem Cell Development by Sensing microRNA-146a in Vertebrates
Hongyan Liu, Kun Zhou, Kai Zhu, Yun-Fei Li, Liyuan Mo, Peng‐Fei Xu, Yan Li
This study identifies microRNA-146a as an endogenous activator of TLR7 signaling, which promotes embryonic HSC development through IRF5 and Notch signaling in zebrafish and mouse embryos.
bioRxiv · Jul 6, 2026 · PreprintDevelopmental Biology