Identifying antisense oligonucleotides to disrupt small RNA regulated antibiotic resistance via a cell-free transcription-translation platform
Min Jen Tsai, Raphael Angelo I. Zambrano, Jeremiah Lyn Susas, Lizette Silva, Melissa K. Takahashi
The paper uses a cell-free TX-TL assay to identify ASOs targeting MicF sRNA, showing synergistic antibiotic sensitivity reduction when targeting multiple regions.
ACS Synthetic Biology · Aug 4, 2023Peer-reviewedSynthetic Biology