Ionizable networks mediate pH-dependent allostery in SH2 signaling proteins
Papa Kobina Van Dyck, Luke J. Piszkin, Elijah A. Gorski, Eduarda Tartarella Nascimento, Joshua A. Abebe, Logan M. Hoffmann, Jeffrey W. Peng, Katharine A. White
This paper investigates how pH dynamics regulate SH2 signaling proteins like SHP2 and Src through allosteric mechanisms involving ionizable networks.
Science Signaling · Nov 11, 2025Peer-reviewedBiochemistry