Katharine A. White

This paper shows that intracellular pH regulates beta-catenin stability and function, with low pH increasing its abundance and activity while high pH decreases it.

This paper investigates how pH dynamics regulate SH2 signaling proteins like SHP2 and Src through allosteric mechanisms involving ionizable networks.

This study shows that ECM stiffness affects intracellular pH, which mediates vasculogenic mimicry through β-catenin in cancer cells.

The paper analyzes amino acid mutation patterns across 29 cancers, identifying six mutation signatures, five of which are validated using COSMIC data.