N-myc Downstream Regulated Gene 1 (NDRG1) functions as a molecular switch for cellular adaptation to hypoxia
Jong S. Park, Austin M. Gabel, Polina Kassir, Lois Kang, Prableen K Chowdhary, Afia Osei-Ntansah, Neil D. Tran, Soujanya Viswanathan, Bryanna Isela-Inez Canales, Pengfei Ding, Young‐Sam Lee, Rachel M. Brewster
This study identifies Ndrg1a as a molecular switch that facilitates hypoxia adaptation by promoting NKA degradation, preserving ATP in kidney and ionocytes of zebrafish embryos.
eLife · Sep 16, 2022Peer-reviewedDevelopmental Biology