Repair of leukemia-associated single nucleotide variants via interallelic gene conversion
Alexander James Silver, Donovan J. Brown, Sarah D. Olmstead, Jackson M Watke, Agnieszka E. Gorska, Londa Tanner, Haley Elizabeth Ramsey, Michael Robert Savona
This study demonstrates that CRISPR-mediated interallelic gene conversion can revert heterozygous SNVs in leukemia cells without exogenous templates, improving survival in xenograft models.
Gene · Apr 11, 2025Peer-reviewedCancer Biology