Author

Donovan J. Brown

Vanderbilt University Medical CenterORCID 0000-0003-3820-7050Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alexander James SilveriD· 2 shared Michael Robert SavonaiD· 2 shared Agnieszka E. GorskaiD· 1 shared Alexander G. BickiD· 1 shared Alyssa ParkeriD· 1 shared Ayesha Ahmad· 1 shared Brian SharberiD· 1 shared Caitlyn VlasschaertiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Alexander James SilverORCID

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2 papers

Recent·Most cited

Cancer BiologyGenePeer-reviewedApr 11, 2025

Repair of leukemia-associated single nucleotide variants via interallelic gene conversion

Alexander James Silver, Donovan J. Brown, Sarah D. Olmstead…·Michael Robert Savona

This study demonstrates that CRISPR-mediated interallelic gene conversion can revert heterozygous SNVs in leukemia cells without exogenous templates, improving survival in xenograft models.

4 citations

humanwhole-genome sequencing

𝕏 PostBluesky

GeneticsBlood AdvancesPeer-reviewedMar 20, 2024

Multiomic Profiling of Human Clonal Hematopoiesis Reveals Genotype and Cell-Specific Inflammatory Pathway Activation

Jonathan Brett Heimlich, Pawan K. Bhat, Alyssa Parker…·Paul Brent Ferrell

This study profiles single-cell multiomic data from clonal hematopoiesis patients and controls, revealing pro-inflammatory profiles in monocytes and T cell dysfunction.

42 citationstop 1%

humanscRNA-seq

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