Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life
Kaushik Bhattacharya, Samarpan Maiti, Szabolcs Zahorán, Lorenz Weidenauer, Dina Hany, Diana Wider, Lilia Bernasconi, Manfredo Quadroni, Martine A. Collart, Didier Picard
The paper shows that mammalian cells can maintain critical Hsp90 levels through translational reprogramming in response to stress, ensuring viability despite genetic loss of Hsp90 alleles.
Nature Communications · Oct 21, 2022Peer-reviewedMolecular Biology