IL-23 licenses the transition from preclinical autoimmunity to inflammatory arthritis through IL-17A-dependent mechanisms
Matthias Jarlborg, Alexandra Circiumaru, Celine Lamacchia, Laurie Vaillant, Erik Rakotoarijaonina, Koen Venken, Dirk Elewaut, Emiliana Rodriguez, Assunta Caruso, Arnaud Huard, Luca Santuari, Nylsa Chammartin, Delphine S Courvoisier, Massimo Andreatta, Santiago J Carmona, , Cem Gabay
This study shows IL-23 promotes the transition from preclinical autoimmunity to arthritis by enhancing IL-17A and IFN-gamma production, and identifies IL-23 pathway changes in at-risk individuals.
bioRxiv · Nov 4, 2026 · PreprintImmunology