Author

Lucas B Jacob

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Alessandra M. Larimer-PiccianiiD· 1 shared José‐Alain SaheliD· 1 shared Kacey J. Sullinger· 1 shared Leah C. ByrneiD· 1 shared Wyatt G Kriebel· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

Alessandra M. Larimer-PiccianiORCID

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1 paper

Recent·Most cited

Systemic, RPE-directed AAV-Tyrosinase therapy restores ocular pigmentation in an OCA1 mouse model

Alessandra M. Larimer-Picciani, Lucas B Jacob, Kacey J. Sullinger, Wyatt G Kriebel, José‐Alain Sahel, Leah C. Byrne

This study demonstrates that systemic delivery of an RPE-directed AAV-Tyr vector restores ocular pigmentation and reduces photophobia in an OCA1 mouse model.

bioRxiv · Jul 2, 2026 · PreprintMolecular Biology