José‐Alain Sahel

This paper identifies an AKT1-TERT-FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE cells under stress.

This study demonstrates that systemic delivery of an RPE-directed AAV-Tyr vector restores ocular pigmentation and reduces photophobia in an OCA1 mouse model.

The paper develops a new AAV engineering workflow, scAAVengr-Hunt, to create potent vectors and identifies a structural mechanism underlying their broad species and tissue potency.

This study identifies 63 AMD risk loci across multiple ancestries, highlighting ancestry-dependent genetic heterogeneity and potential therapeutic targets.

This paper introduces a method to quickly map multifocal pupillary response fields using frequency tagging, showing it can distinguish patients from healthy individuals with high accuracy.

This study shows that spatial memory in older adults is impaired for objects in the upper visual field, suggesting vertical position affects memory performance.

This study shows that children and older adults can use allocentric navigation strategies equally when geometric cues are available, challenging the idea that strategy preference is age-related.

The paper investigates neural coding of object, feature, and geometry spatial cues in humans using fMRI, finding synergistic hippocampal-striatal interactions and distinct neural signatures for each cue type.

This study shows that optogenetic stimulation of the primate retina can activate the visual cortex for over 20 months, demonstrating long-term functionality and signal transmission.

This paper demonstrates sonogenetic stimulation of the brain with high spatiotemporal resolution for visual restoration in rats and rodents.

This study uses optogenetics and functional ultrasound imaging to show that surface stimulation of the rat visual cortex activates a large volume of V1, including deep layers and areas beyond V1.

The paper uses mobile EEG to study landmark-based navigation in virtual reality, identifying brain areas and neural modulations involved in spatial learning and behavior.

The paper evaluates an optogenetic construct for vision restoration in non-human primates, demonstrating high temporal resolution and visual acuity above legal blindness.

This study uses functional ultrasound imaging to map retinotopic and ocular dominance columns in the visual cortex of awake non-human primates with high spatiotemporal resolution.

This study demonstrates that optogenetically activated ganglion cells in mouse and macaque retinas have high spatial resolution, predicting acuity above legal blindness limits.