Solvation Shapes the Conformational Landscape of a Therapeutically Relevant SMN2 Splice-Site Defect
Mohammed Khaled, Lucas Leuschner, Oscar Palomino‐Hernández
The paper investigates the conformational landscape of a SMN2 splice-site defect using molecular dynamics simulations and shows that solvation models significantly affect the equilibrium between different conformations.
bioRxiv · Jul 6, 2026 · PreprintBiophysics