Oscar Palomino‐Hernández

The paper investigates the conformational landscape of a SMN2 splice-site defect using molecular dynamics simulations and shows that solvation models significantly affect the equilibrium between different conformations.

The paper maps the conformational landscape of TRMT2A RRM using molecular dynamics and identifies a hydrophobic cluster that governs allostery and RNA recognition.

The paper investigates protonation states in the Endothiapepsin/PepstatinA complex using computational and experimental methods, revealing non-default protonation states and their impact on binding energy calculations.

The paper identifies and validates small-molecule inhibitors of TRMT2A that reduce polyQ aggregation and cell death in human cells.