Modelling Medial Degenerative Features by Enzymatic Digestion to Evaluate Disease-Relevant Structure-Function Relationships in the Thoracic Aorta
Daniella Eliathamby, Lucas Ung, Hayley W Y Yap, Malak Elbatarny, Maral Ouzounian, Michelle Patricia Bendeck, Michael A. Seidman, Craig A. Simmons, Jennifer Chia-Ying Chung
This study uses enzymatic digestion to model ECM degeneration in aortic tissue and identifies biomechanical impacts of elastin, collagen, and proteoglycan degradation.
bioRxiv · Feb 9, 2026 · PreprintBioengineering