Craig A. Simmons

This study identifies miR-9-5p as a regulator of cardiomyocyte hypertrophy and contractility in HCM using iPSC models and miRNA profiling.

This study uses enzymatic digestion to model ECM degeneration in aortic tissue and identifies biomechanical impacts of elastin, collagen, and proteoglycan degradation.

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.

This study examines structural and mechanical changes in the main pulmonary artery in pulmonary arterial hypertension and links them to impaired right ventricular function and coupling.

This study shows that tissue-engineered heart valves with native biaxial mechanical properties perform better and avoid fibrosis compared to those with non-physiological mechanics.

This study shows that a myosin ATPase inhibitor reverses HCM phenotypes in pediatric iPSC-cardiomyocytes, with effects dependent on the underlying genetic variant.