Author

Lucie S Taylor

Newcastle upon Tyne Hospitals NHS Foundation Trust

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Robert William TayloriD· 3 shared Andrew Michael FreyiD· 2 shared Charlotte L. AlstoniD· 2 shared Ilka WittigiD· 2 shared Karen Lucy StalsiD· 2 shared Langping HeiD· 2 shared Monika Winter· 2 shared Sila Hopton· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Robert William TaylorORCID

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3 papers

Recent·Most cited

Bi-allelic UQCC1 variants impair mitochondrial complex III assembly causing early-onset mitochondrial disease

Sarah J. Smith, Samira Ait-El-Mkadem Saadi, Jamie K. Leighton, Lucie S Taylor, Andrew Michael Frey, Michael G. Nelson, Paulina Castañeda-Támez, Emmanuelle C. Genin, Richard C. Caswell, Abeer Dannoura, Hanan E. Shamsheldin, Konstantina Fragaki, Cécile Rouzier, Langping He, Mahmoud R. Fassad, , Robert William Taylor

This study identifies biallelic UQCC1 variants as a cause of early-onset mitochondrial disease by impairing complex III assembly and function.

medRxiv · Oct 19, 2026 · PreprintGenetic & Genomic Medicine

De novo truncation variants in the low-complexity C-terminal region of XRN1 are associated with a dominant form of lethal infantile mitochondrial cardiomyopathy

Liana N. Semcesen, Lucie S Taylor, Leah E. Frajman, Marisa W. Friederich, Andrew Michael Frey, Stefan J. Siira, Daniella Helena Hock, Tegan L. Stait, Sila Hopton, Yoshihito Kishita, Queenie K.‐G. Tan, Vandana Shashi, Muriel Holder-Espinasse, Hugh A. Lemonde, Kay Metcalfe, , Alison G. Compton

The paper identifies de novo truncating variants in XRN1's C-terminal region causing lethal infantile mitochondrial cardiomyopathy by disrupting its interaction with EDC4.

medRxiv · Jan 11, 2026 · PreprintGenetic & Genomic Medicine

COA5 has an essential role in the early stage of mitochondrial complex IV assembly

Jia Xin Tang, Alfredo Cabrera‐Orefice, Jana Meisterknecht, Lucie S Taylor, Geoffray Monteuuis, Maria Stensland, Adam Szczepanek, Karen Lucy Stals, James E. Davison, Langping He, Sila Hopton, Tuula A. Nyman, Christopher Benjamin Jackson, Angela Pyle, Monika Winter, , Robert William Taylor

The paper identifies a COA5 missense variant causing isolated mitochondrial complex IV assembly impairment in two siblings and validates its role in early CIV assembly using patient-derived cells and CRISPR/Cas9 knockout models.

Life Science Alliance · Jan 8, 2025Peer-reviewedGenetic & Genomic Medicine