Christopher Benjamin Jackson

This study shows that NAD+ precursor treatment improves cardiac function but worsens erythroid maturation in mitochondrial progeria, highlighting tissue-specific effects of NAD+ boosting.

This study identifies enhanced mitochondrial respiration and glutamine-dependent TCA cycle as vulnerabilities in MYChigh breast cancer cells, showing synthetic lethality with complex I inhibitors.

The paper identifies a COA5 missense variant causing isolated mitochondrial complex IV assembly impairment in two siblings and validates its role in early CIV assembly using patient-derived cells and CRISPR/Cas9 knockout models.

The paper investigates the functional roles of 14 unique human mitochondrial ribosomal proteins in the small subunit, showing their essentiality in assembly and translation, with a redox-regulated role for mS37.

The paper investigates how pathogenic variants in MT-ATP6 affect mitochondrial protein synthesis quality control and reveals distinct regulatory consequences on mitochondrial gene expression.