Much ado about nothing: Modelling amino acid replacement with predicted protein structures
Lukas Buschmann, Sarah Naomi Bolz, Ferras El-Hendi, Negin Malekian, Michael Schroeder
The paper benchmarks a new substitution matrix derived from AlphaFold-predicted structures against existing matrices, finding similar performance and highlighting the diminishing role of substitution matrices with more sequence data.
Bioinformatics · Apr 24, 2026Peer-reviewedBioinformatics